Endocrine Abstracts

Background: Long-term glucocorticoids can result in iatrogenic Cushing’s syndrome with adrenal suppression. Most patients reactivate their hypothalamic-pituitary-adrenal axis once they’re weaned off glucocorticoids. During glucocorticoid withdrawal, many clinicians switch patients to hydrocortisone to benefit from its short half-life1. However, in some patients, hypothalamic-pituitary-adrenal axis recovery is delayed despite the above. It is unclear whethe...

Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and poor prognosis. Lactate dehydrogenase (LDH) is an enzyme of the glycolytic pathway that is associated with tumour progression in several cancers. To date, evidence on the prognostic value of LDH in ACC is limited.Aims: To assess the impact of LDH in disease-free survival (DFS) in operated ACC.Materials and methods: Retrospective cohort study ...

Aim: The aim of this study was to evaluate the association between thyroid function in Graves’ disease (GD) with high-sensitivity C-reactive protein (hs-CRP), lipid profile, homocysteine, folate, vitamin B12 and insulin resistance.Methods: We performed a cross-sectional of 104 patients with recently diagnosed GD. All participants were in the first cycle of treatment with methimazole. We collected demographic information, body mass indexes (BMI), lab...

Introduction: This study presents four clinical cases of lipodystrophies, which are a group of rare and heterogeneous diseases characterized by the decrease or lack of adipose tissue (AT) accompanied by metabolic complications.Clinical cases: 1) 59-year-old woman with partial familial lipodystrophy, type 7 (OMIM #606721): Diagnosis of suspected type 1 diabetes (DM) at 28 (treated with insulin with poor control), class 1 obesity and hypertriglyceridemia. ...

Introduction: Acute hyperlipidemic pancreatitis is a rare clinical entity that usually affects patients with previous lipid alterations (triglyceride concentration >500 mg/dl) associated with triggering secondary factors, such as poorly controlled diabetes mellitus (DM).Clinical Case: We present the case of a 60-year-old man who came to the Emergency Department with a picture of acute abdominal pain secondary to acute pancreatitis in which a small hy...

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

Background: To describe trends in the incidence and outcomes for vascular dementia in elderly patients with and without type 2 diabetes (T2DM) in Spain between 2004 and 2013.Methods: We used National Hospital Discharge Data to select all patients aged 70 years or over discharged from hospital with a vascular dementia primary diagnosis. Discharges were grouped by diabetes status (T2DM or non-diabetic). Incidence was calculated overall and stratified by di...

Introduction: Clinical trials indicate that Tolvaptan is safe and effective in the treatment of patients with sustained mild/moderate SIADH-induced euvolemic hyponatremia. Tolvaptan doses are often modified during chronic use. We present the weekly doses of a series of patients on chronic therapy, followed up in outpatient clinic.Methods: Retrospective, cross-sectional. 114 patients receiving tolvaptan for chronic SIADH were followed up in a Hyponatremia...

Background: Dumping syndrome (DS) and post-bariatric hypoglycemia (PBH) are some of the most challenging problems encountered during the follow-up of bariatric surgery (BS), especially after Roux-en-y gastric bypass (yRGB). When pharmacological and dietary treatment fail to control DS and PBH, surgical revision is often the next therapeutic step. Endoscopic treatment with argon plasma coagulation (APC) may be an alternative treatment by reducing the diameter of the gastro-jeju...

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...